Digital Drosophila Archive
70 lines
2.8 KiB
JSON
70 lines
2.8 KiB
JSON
{
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"status": "TRANSMITTER-IDENTITY-INTERPRETATION-WARNING",
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"DAN_label_definition_in_4W": "neurotransmitter metadata equals dopamine, not independently verified anatomical DAN identity",
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"DPM_input_metadata": [
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{
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"neuron_idx": 2403,
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"body_id": 12569,
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"annotation_class": null,
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"annotation_type": "DPM",
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"annotation_subclass": null,
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"annotation_superclass": "cb_intrinsic",
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"neurotransmitter": "dopamine",
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"audit_category": "DAN"
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}
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],
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"late_positive_contributions": [
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{
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"target_neuron_idx": 59832,
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"DPM_fraction_all_positive": 0.0706060454249382,
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"DPM_fraction_metadata_dopamine_positive": 0.29459211230278015,
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"metadata_dopamine_fraction_all_positive": 0.239673912525177
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},
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{
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"target_neuron_idx": 78836,
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"DPM_fraction_all_positive": 0.3121650218963623,
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"DPM_fraction_metadata_dopamine_positive": 0.3416522741317749,
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"metadata_dopamine_fraction_all_positive": 0.9136922359466553
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},
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{
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"target_neuron_idx": 82312,
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"DPM_fraction_all_positive": 0.0,
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"DPM_fraction_metadata_dopamine_positive": 0.0,
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"metadata_dopamine_fraction_all_positive": 0.00624917633831501
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}
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],
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"frozen_signs_changed": false,
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"simulations_rerun": false,
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"conclusion": "Do not interpret omit_DAN as selective removal of confirmed reward DANs. It removes the operational metadata-dopamine group, including DPM.",
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"causal_limit": "Neither DPM-only necessity nor whole-brain causal necessity was tested. Literature is not proof of the true transmitter/sign for these exact MaleCNS bodies.",
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"source_access": {
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"Haynes2015": "PMC full text retrieved",
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"Eckstein2024": "PubMed bibliographic record and PMC/ETH search-index excerpts; PMC CAPTCHA and ETH direct PDF 403",
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"MaleCNS_authors_repository": "https://github.com/funkelab/synister_malecns"
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},
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"sources": [
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{
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"title": "Haynes et al. 2015, A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster",
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"url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4305081/",
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"doi": "10.7554/eLife.03868"
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},
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{
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"title": "Eckstein et al. 2024, Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster",
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"url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11106717/",
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"doi": "10.1016/j.cell.2024.03.016"
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}
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],
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"sealed_4W_integrity_before": {
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"root": "/data/digital-drosophila/experiments/phase4w-late-kc-feedback",
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"checked": 214,
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"pass": true,
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"control_sha256": "cbc90feefc335c1b49f2121e5364459dc2f1c6d4dc6d5b3cf1a7ecb1a5058dc7"
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},
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"sealed_4W_integrity_after": {
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"root": "/data/digital-drosophila/experiments/phase4w-late-kc-feedback",
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"checked": 214,
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"pass": true,
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"control_sha256": "cbc90feefc335c1b49f2121e5364459dc2f1c6d4dc6d5b3cf1a7ecb1a5058dc7"
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}
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}
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