Digital Drosophila Archive
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37 KiB
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{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:47:41Z","timestamp":1789469261292,"version":"build-2803163510"},"reference-count":87,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS097237"],"award-info":[{"award-number":["R01NS097237"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS114403"],"award-info":[{"award-number":["R01NS114403"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00MH092294"],"award-info":[{"award-number":["R00MH092294"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001391","name":"Whitehall Foundation","doi-asserted-by":"publisher","award":["2014-12-31"],"award-info":[{"award-number":["2014-12-31"]}],"id":[{"id":"10.13039\/100001391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35NS097224"],"award-info":[{"award-number":["R35NS097224"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science & Technology Commission","doi-asserted-by":"crossref","award":["Z181100001318002"],"award-info":[{"award-number":["Z181100001318002"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Brain Initiative of Beijing Municipal Science & Technology Commission","award":["Z181100001518004"],"award-info":[{"award-number":["Z181100001518004"]}]},{"name":"Guangdong Grant \"Key Technologies for Treatment of Brain Disorders\"","award":["2018B030332001"],"award-info":[{"award-number":["2018B030332001"]}]},{"name":"General Program of National Natural Science Foundation of China Projects","award":["31671118"],"award-info":[{"award-number":["31671118"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS103558"],"award-info":[{"award-number":["NS103558"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"General Program of National Natural Science Foundation of China Projects","doi-asserted-by":"publisher","award":["31925017"],"award-info":[{"award-number":["31925017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"General Program of National Natural Science Foundation of China Projects","doi-asserted-by":"publisher","award":["31871087"],"award-info":[{"award-number":["31871087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,3,11]]},"abstract":"<jats:p>\n Anatomical and physiological compartmentalization of neurons is a mechanism to increase the computational capacity of a circuit, and a major question is what role axonal compartmentalization plays. Axonal compartmentalization may enable localized, presynaptic plasticity to alter neuronal output in a flexible, experience-dependent manner. Here, we show that olfactory learning generates compartmentalized, bidirectional plasticity of acetylcholine release that varies across the longitudinal compartments of\n <jats:italic>Drosophila<\/jats:italic>\n mushroom body (MB) axons. The directionality of the learning-induced plasticity depends on the valence of the learning event (aversive vs. appetitive), varies linearly across proximal to distal compartments following appetitive conditioning, and correlates with learning-induced changes in downstream mushroom body output neurons (MBONs) that modulate behavioral action selection. Potentiation of acetylcholine release was dependent on the Ca\n <jats:sub>V<\/jats:sub>\n 2.1 calcium channel subunit\n <jats:italic>cacophony<\/jats:italic>\n . In addition, contrast between the positive conditioned stimulus and other odors required the inositol triphosphate receptor, which maintained responsivity to odors upon repeated presentations, preventing adaptation. Downstream from the MB, a set of MBONs that receive their input from the \u03b33 MB compartment were required for normal appetitive learning, suggesting that they represent a key node through which reward learning influences decision-making. These data demonstrate that learning drives valence-correlated, compartmentalized, bidirectional potentiation, and depression of synaptic neurotransmitter release, which rely on distinct mechanisms and are distributed across axonal compartments in a learning circuit.\n <\/jats:p>","DOI":"10.7554\/elife.76712","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T09:15:20Z","timestamp":1647249320000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.76712","source":"Crossref","is-referenced-by-count":34,"title":["Associative learning drives longitudinally graded presynaptic plasticity of neurotransmitter release along axonal compartments"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-1101","authenticated-orcid":true,"given":"Aaron","family":"Stahl","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02dxx6824","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neuroscience, The 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IDG\/McGovern Institute for Brain Research","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanikea B","family":"King","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02dxx6824","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neuroscience, The Scripps Research Institute","place":["Jupiter, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/029819q61","id-type":"ROR","asserted-by":"publisher"}],"name":"Chinese Institute for Brain Research","place":["Beijing, China"]},{"id":[{"id":"https:\/\/ror.org\/02v51f717","id-type":"ROR","asserted-by":"publisher"}],"name":"Peking-Tsinghua Center for Life Sciences, Peking University","place":["Beijing, China"]},{"id":[{"id":"https:\/\/ror.org\/02v51f717","id-type":"ROR","asserted-by":"publisher"}],"name":"State Key Laboratory of Membrane 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