Digital Drosophila Archive
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1 line
35 KiB
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Here, we show the dorsal paired medial (DPM) neurons, which are required for memory consolidation in Drosophila, are sleep-promoting inhibitory neurons. DPMs increase sleep via release of GABA onto wake-promoting mushroom body (MB) \u03b1'\/\u03b2' neurons. Functional imaging demonstrates that DPM activation evokes robust increases in chloride in MB neurons, but is unable to cause detectable increases in calcium or cAMP. Downregulation of \u03b1'\/\u03b2' GABAA and GABABR3 receptors results in sleep loss, suggesting these receptors are the sleep-relevant targets of DPM-mediated inhibition. Regulation of sleep by neurons necessary for consolidation suggests that these brain processes may be functionally interrelated via their shared anatomy. These findings have important implications for the mechanistic relationship between sleep and memory consolidation, arguing for a significant role of inhibitory neurotransmission in regulating these processes.<\/jats:p>","DOI":"10.7554\/elife.03868","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T07:33:34Z","timestamp":1420616014000},"source":"Crossref","is-referenced-by-count":176,"title":["A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster"],"prefix":"10.7554","volume":"4","author":[{"given":"Paula R","family":"Haynes","sequence":"first","affiliation":[{"name":"Department of Biology, Volen Center for Complex Systems, National Center for Behavioral Genomics, Brandeis University, Waltham, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany L","family":"Christmann","sequence":"additional","affiliation":[{"name":"Department of Biology, Volen Center for Complex Systems, National Center for Behavioral Genomics, Brandeis University, Waltham, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie C","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Biology, Volen Center for Complex Systems, National Center for Behavioral Genomics, Brandeis University, Waltham, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2015,1,7]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"R774","DOI":"10.1016\/j.cub.2013.07.025","article-title":"Sleep, plasticity and memory from molecules to whole-brain networks","volume":"23","author":"Abel","year":"2013","journal-title":"Current Biology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/nn2046","article-title":"Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila","volume":"11","author":"Agosto","year":"2008","journal-title":"Nature Neuroscience"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"13819","DOI":"10.1523\/JNEUROSCI.2601-12.2012","article-title":"Optimization of a GCaMP calcium indicator for neural activity imaging","volume":"32","author":"Akerboom","year":"2012","journal-title":"The Journal of Neuroscience"},{"key":"bib4","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511623257","volume-title":"Modeling Brain Function\u2013The World of Attractor Neural Networks","author":"Amit","year":"1989"},{"key":"bib5","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1242\/jeb.205.9.1233","article-title":"Drosophila as a new model organism for the neurobiology of aggression?","volume":"205","author":"Baier","year":"2002","journal-title":"The Journal of Experimental Biology"},{"key":"bib6","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1523\/JNEUROSCI.21-05-01523.2001","article-title":"Altered electrical properties in Drosophila neurons developing without synaptic transmission","volume":"21","author":"Baines","year":"2001","journal-title":"The Journal of Neuroscience"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1162\/089976698300017827","article-title":"Stable and rapid recurrent processing in realistic autoassociative memories","volume":"10","author":"Battaglia","year":"1998","journal-title":"Neural Computation"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1093\/cercor\/bhl117","article-title":"Immunoreactivity for the GABAA receptor alpha1 subunit, somatostatin and Connexin36 distinguishes axoaxonic, basket, and bistratified interneurons of the rat hippocampus","volume":"17","author":"Baude","year":"2007","journal-title":"Cerebral Cortex"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"e20800","DOI":"10.1371\/journal.pone.0020800","article-title":"The serotonin 5-HT7Dro receptor is expressed in the brain of Drosophila, and is essential for normal courtship and mating","volume":"6","author":"Becnel","year":"2011","journal-title":"PLOS ONE"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1016\/j.cub.2013.05.029","article-title":"Essential role of the mushroom body in context-dependent CO(2) avoidance in Drosophila","volume":"23","author":"Br\u00e4cker","year":"2013","journal-title":"Current Biology"},{"key":"bib11","first-page":"155","article-title":"Nutritional Substitution- a new approach to microbial control for Drosophila cultures","volume":"51","author":"Brent","year":"1974","journal-title":"Dro. 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