Digital Drosophila Archive
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18 KiB
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In <jats:italic>Drosophila<\/jats:italic>, \u03b1\u03b2 core Kenyon cells (\u03b1\u03b2<jats:sub>c<\/jats:sub> KCs) of the mushroom bodies integrate odor-evoked synaptic inputs to spike threshold at rates that parallel the speed of olfactory choices. Here we perform a causal test of the idea that the biophysical process of synaptic integration underlies the psychophysical process of bounded evidence accumulation in this system. Injections of single brief, EPSP-like depolarizations into the dendrites of \u03b1\u03b2<jats:sub>c<\/jats:sub> KCs during odor discrimination, using closed-loop control of a targeted opsin, accelerate decision times at a marginal cost of accuracy. Model comparisons favor a mechanism of temporal integration over extrema detection and suggest that the optogenetically evoked quanta are added to a growing total of sensory evidence, effectively lowering the decision bound. The subthreshold voltage dynamics of \u03b1\u03b2<jats:sub>c<\/jats:sub> KCs thus form an accumulator memory for sequential samples of information.<\/jats:p>","DOI":"10.1038\/s41467-023-38487-5","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T12:07:42Z","timestamp":1684152462000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transient photocurrents in a subthreshold evidence accumulator accelerate perceptual decisions"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9707-2816","authenticated-orcid":false,"given":"Timothy L. 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