Digital Drosophila Archive
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38 KiB
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In contrast, previous work indicates that\n <jats:italic>Drosophila<\/jats:italic>\n and other invertebrates store memories using presynaptic plasticity of cholinergic synapses. Here, we provide evidence for postsynaptic plasticity at cholinergic output synapses from the\n <jats:italic>Drosophila<\/jats:italic>\n mushroom bodies (MBs). We find that the nicotinic acetylcholine receptor (nAChR) subunit \u03b15 is required within specific MB output neurons for appetitive memory induction but is dispensable for aversive memories. In addition, nAChR \u03b12 subunits mediate memory expression and likely function downstream of \u03b15 and the postsynaptic scaffold protein discs large (Dlg). We show that postsynaptic plasticity traces can be induced independently of the presynapse, and that in vivo dynamics of \u03b12 nAChR subunits are changed both in the context of associative and non-associative (familiarity) memory formation, underlying different plasticity rules. Therefore, regardless of neurotransmitter identity, key principles of postsynaptic plasticity support memory storage across phyla.\n <\/jats:p>","DOI":"10.7554\/elife.80445","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T08:01:57Z","timestamp":1665993717000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.80445","source":"Crossref","is-referenced-by-count":32,"title":["Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1893-6435","authenticated-orcid":true,"given":"Carlotta","family":"Pribbenow","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/001w7jn25","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Neurophysiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and 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