Digital Drosophila Archive
1 line
37 KiB
JSON
1 line
37 KiB
JSON
{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:55:51Z","timestamp":1790337351673,"version":"4.1.0"},"reference-count":114,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR 2705"],"award-info":[{"award-number":["FOR 2705"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,12,28]]},"abstract":"<jats:p>\n To identify and memorize discrete but similar environmental inputs, the brain needs to distinguish between subtle differences of activity patterns in defined neuronal populations. The Kenyon cells (KCs) of the\n <jats:italic>Drosophila<\/jats:italic>\n adult mushroom body (MB) respond sparsely to complex olfactory input, a property that is thought to support stimuli discrimination in the MB. To understand how this property emerges, we investigated the role of the inhibitory anterior paired lateral (APL) neuron in the input circuit of the MB, the calyx. Within the calyx, presynaptic boutons of projection neurons (PNs) form large synaptic microglomeruli (MGs) with dendrites of postsynaptic KCs. Combining electron microscopy (EM) data analysis and in vivo calcium imaging, we show that APL, via inhibitory and reciprocal synapses targeting both PN boutons and KC dendrites, normalizes odour-evoked representations in MGs of the calyx. APL response scales with the PN input strength and is regionalized around PN input distribution. Our data indicate that the formation of a sparse code by the KCs requires APL-driven normalization of their MG postsynaptic responses. This work provides experimental insights on how inhibition shapes sensory information representation in a higher brain centre, thereby supporting stimuli discrimination and allowing for efficient associative memory formation.\n <\/jats:p>","DOI":"10.7554\/elife.74172","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T08:01:09Z","timestamp":1640764869000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.74172","source":"Crossref","is-referenced-by-count":23,"title":["The anterior paired lateral neuron normalizes odour-evoked activity in the Drosophila mushroom body calyx"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5896-9346","authenticated-orcid":true,"given":"Luigi","family":"Prisco","sequence":"first","affiliation":[{"name":"Dynamics of neuronal circuits, German Center for Neurodegenerative Diseases (DZNE)","place":["Bonn, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4678-4926","authenticated-orcid":true,"given":"Stephan Hubertus","family":"Deimel","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurobiology of Behavior, University of G\u00f6ttingen","place":["G\u00f6ttingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Yeliseyeva","sequence":"additional","affiliation":[{"name":"Dynamics of neuronal circuits, German Center for Neurodegenerative Diseases (DZNE)","place":["Bonn, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9745-5145","authenticated-orcid":true,"given":"Andr\u00e9","family":"Fiala","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurobiology of Behavior, University of G\u00f6ttingen","place":["G\u00f6ttingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8679-5515","authenticated-orcid":true,"given":"Gaia","family":"Tavosanis","sequence":"additional","affiliation":[{"name":"Dynamics of neuronal circuits, German Center for Neurodegenerative Diseases (DZNE)","place":["Bonn, Germany"]},{"name":"LIMES, Rheinische Friedrich Wilhelms Universit\u00e4t Bonn","place":["Bonn, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0025-5564(71)90051-4","article-title":"A theory of cerebellar function","volume":"10","author":"Albus","year":"1971","journal-title":"Mathematical Biosciences"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.neuron.2012.06.006","article-title":"The brain activity map project and the challenge of functional connectomics","volume":"74","author":"Alivisatos","year":"2012","journal-title":"Neuron"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56954","article-title":"Localized inhibition in the Drosophila mushroom body","volume":"9","author":"Amin","year":"2020","journal-title":"eLife"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"16606","DOI":"10.1073\/pnas.1921294117","article-title":"Mechanisms underlying homeostatic plasticity in the Drosophila mushroom body in vivo","volume":"117","author":"Apostolopoulou","year":"2020","journal-title":"PNAS"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1080\/01677060802471718","article-title":"The mushroom body of adult Drosophila characterized by GAL4 drivers","volume":"23","author":"Aso","year":"2009","journal-title":"Journal of Neurogenetics"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04577","article-title":"The neuronal architecture of the mushroom body provides a logic for associative learning","volume":"3","author":"Aso","year":"2014","journal-title":"eLife"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/nn1947","article-title":"Adaptive regulation of sparseness by feedforward inhibition","volume":"10","author":"Assisi","year":"2007","journal-title":"Nature Neuroscience"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108871","article-title":"Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation","volume":"34","author":"Baltruschat","year":"2021","journal-title":"Cell Reports"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1523\/JNEUROSCI.2598-13.2014","article-title":"Differential associative training enhances olfactory acuity in Drosophila melanogaster","volume":"34","author":"Barth","year":"2014","journal-title":"The Journal of Neuroscience"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1016\/j.cub.2020.06.042","article-title":"Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain","volume":"30","author":"Bates","year":"2020","journal-title":"Current Biology"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1016\/j.cub.2008.09.045","article-title":"MicroRNA processing pathway regulates olfactory neuron morphogenesis","volume":"18","author":"Berdnik","year":"2008","journal-title":"Current Biology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1038\/nn1976","article-title":"Sensory processing in the Drosophila antennal lobe increases reliability and separability of ensemble odor representations","volume":"10","author":"Bhandawat","year":"2007","journal-title":"Nature Neuroscience"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1113\/jphysiol.1996.sp021806","article-title":"Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors","volume":"497","author":"Brickley","year":"1996","journal-title":"The Journal of Physiology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1002\/cne.23037","article-title":"Different classes of input and output neurons reveal new features in microglomeruli of the adult Drosophila mushroom body calyx","volume":"520","author":"Butcher","year":"2012","journal-title":"The Journal of Comparative Neurology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"10568","DOI":"10.1523\/JNEUROSCI.0682-12.2013","article-title":"Imaging a population code for odor identity in the Drosophila mushroom body","volume":"33","author":"Campbell","year":"2013","journal-title":"The Journal of Neuroscience"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-017-01109-y","article-title":"Sparse synaptic connectivity is required for decorrelation and pattern separation in feedforward networks","volume":"8","author":"Cayco-Gajic","year":"2017","journal-title":"Nature Communications"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.neuron.2019.01.044","article-title":"Re-evaluating Circuit Mechanisms Underlying Pattern Separation","volume":"101","author":"Cayco-Gajic","year":"2019","journal-title":"Neuron"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"12430","DOI":"10.1523\/JNEUROSCI.4897-11.2013","article-title":"Granule cell ascending axon excitatory synapses onto Golgi cells implement a potent feedback circuit in the cerebellar granular layer","volume":"33","author":"Cesana","year":"2013","journal-title":"The Journal of Neuroscience"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nature12354","article-title":"Ultrasensitive fluorescent proteins for imaging neuronal activity","volume":"499","author":"Chen","year":"2013","journal-title":"Nature"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.1101\/2020.01.16.909465","article-title":"NeuPrint: Analysis Tools for EM Connectomics","volume-title":"bioRxiv","author":"Clements","year":"2020"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/s0896-6273(00)81093-4","article-title":"A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila","volume":"22","author":"Clyne","year":"1999","journal-title":"Neuron"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1101\/lm.5.1.38","article-title":"Tripartite Mushroom Body Architecture Revealed by Antigenic Markers","volume":"5","author":"Crittenden","year":"1998","journal-title":"Learning & Memory"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.neuron.2016.12.019","article-title":"In Vivo Imaging of Dentate Gyrus Mossy Cells in Behaving Mice","volume":"93","author":"Danielson","year":"2017","journal-title":"Neuron"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1126\/science.8303280","article-title":"Associative odor learning in Drosophila abolished by chemical ablation of mushroom bodies","volume":"263","author":"de Belle","year":"1994","journal-title":"Science"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-64060-x","article-title":"In vivo large-scale analysis of Drosophila neuronal calcium traces by automated tracking of single somata","volume":"10","author":"Delestro","year":"2020","journal-title":"Scientific Reports"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/35078077","article-title":"Disruption of neurotransmission in Drosophila mushroom body blocks retrieval but not acquisition of memory","volume":"411","author":"Dubnau","year":"2001","journal-title":"Nature"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"13099","DOI":"10.1073\/pnas.1510249112","article-title":"Control of cerebellar granule cell output by sensory-evoked Golgi cell inhibition","volume":"112","author":"Duguid","year":"2015","journal-title":"PNAS"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/J.TINS.2008.09.007","article-title":"Timing and Plasticity in the Cerebellum: Focus on the Granular Layer","volume":"32","author":"D\u2019Angelo","year":"2009","journal-title":"Trends in Neurosciences"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/bf03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behavior Research Methods"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/nature14284","article-title":"Temperature representation in the Drosophila brain","volume":"519","author":"Frank","year":"2015","journal-title":"Nature"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/77680","article-title":"Convergent projections of Drosophila olfactory neurons to specific glomeruli in the antennal lobe","volume":"3","author":"Gao","year":"2000","journal-title":"Nature Neuroscience"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.neuron.2008.08.010","article-title":"The neural substrate of spectral preference in Drosophila","volume":"60","author":"Gao","year":"2008","journal-title":"Neuron"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/a:1024460700856","article-title":"Design parameters of the fan-out phase of sensory systems","volume":"15","author":"Garc\u00eda-Sanchez","year":"2003","journal-title":"Journal of Computational Neuroscience"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.neuron.2016.12.026","article-title":"Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus","volume":"93","author":"GoodSmith","year":"2017","journal-title":"Neuron"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.neuron.2008.12.033","article-title":"Motor control in a Drosophila taste circuit","volume":"61","author":"Gordon","year":"2009","journal-title":"Neuron"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1016\/j.celrep.2016.08.063","article-title":"Elucidating the Neuronal Architecture of Olfactory Glomeruli in the Drosophila Antennal Lobe","volume":"16","author":"Grabe","year":"2016","journal-title":"Cell Reports"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.neuron.2010.02.028","article-title":"Retinal parallel processors: more than 100 independent microcircuits operate within a single interneuron","volume":"65","author":"Grimes","year":"2010","journal-title":"Neuron"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.cell.2018.03.075","article-title":"Dendritic Integration of Sensory Evidence in Perceptual Decision-Making","volume":"173","author":"Groschner","year":"2018","journal-title":"Cell"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1038\/nn.3547","article-title":"Integration of the olfactory code across dendritic claws of single mushroom body neurons","volume":"16","author":"Gruntman","year":"2013","journal-title":"Nature Neuroscience"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nature00974","article-title":"An ultra-sparse code underlies the generation of neural sequences in a songbird","volume":"419","author":"Hahnloser","year":"2002","journal-title":"Nature"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.cell.2006.01.050","article-title":"Coding of odors by a receptor repertoire","volume":"125","author":"Hallem","year":"2006","journal-title":"Cell"},{"key":"bib42","doi-asserted-by":"publisher","DOI":"10.3791\/60288","article-title":"In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster","volume":"152","author":"Hancock","year":"2019","journal-title":"Journal of Visualized Experiments"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/gene.10137","article-title":"GETDB, a database compiling expression patterns and molecular locations of a collection of Gal4 enhancer traps","volume":"34","author":"Hayashi","year":"2002","journal-title":"Genesis"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/01677068509100140","article-title":"Drosophila mushroom body mutants are deficient in olfactory learning","volume":"2","author":"Heisenberg","year":"1985","journal-title":"Journal of Neurogenetics"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"11772","DOI":"10.1523\/JNEUROSCI.1099-11.2011","article-title":"Cellular-resolution population imaging reveals robust sparse coding in the Drosophila mushroom body","volume":"31","author":"Honegger","year":"2011","journal-title":"The Journal of Neuroscience"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1038\/nn.2442","article-title":"Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map","volume":"12","author":"Hong","year":"2009","journal-title":"Nature Neuroscience"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1162\/089976604774201613","article-title":"Learning classification in the olfactory system of insects","volume":"16","author":"Huerta","year":"2004","journal-title":"Neural Computation"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.neuron.2017.06.039","article-title":"Origins of Cell-Type-Specific Olfactory Processing in the Drosophila Mushroom Body Circuit","volume":"95","author":"Inada","year":"2017","journal-title":"Neuron"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/J.CELL.2007.01.040","article-title":"Comprehensive Maps of Drosophila Higher Olfactory Centers: Spatially Segregated Fruit and Pheromone Representation","volume":"128","author":"Jefferis","year":"2007","journal-title":"Cell"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1523\/JNEUROSCI.4171-06.2007","article-title":"A Simple Connectivity Scheme for Sparse Coding in an Olfactory System","volume":"27","author":"Jortner","year":"2007","journal-title":"Journal of Neuroscience"},{"key":"bib51","doi-asserted-by":"publisher","DOI":"10.3389\/FNINF.2014.00080\/BIBTEX","article-title":"SIMA: Python Software for Analysis of Dynamic Fluorescence Imaging Data","volume":"8","author":"Kaifosh","year":"2014","journal-title":"Frontiers in Neuroinformatics"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.mod.2007.10.012","article-title":"Conversion of plasma membrane topology during epithelial tube connection requires Arf-like 3 small GTPase in Drosophila","volume":"125","author":"Kakihara","year":"2008","journal-title":"Mechanisms of Development"},{"key":"bib53","volume-title":"Sparse Distributed Memory, A Study of Psychologically Driven Storage","author":"Kanerva","year":"1988"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"8955","DOI":"10.1523\/JNEUROSCI.5469-07.2008","article-title":"Synaptic and cellular properties of the feedforward inhibitory circuit within the input layer of the cerebellar cortex","volume":"28","author":"Kanichay","year":"2008","journal-title":"The Journal of Neuroscience"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1016\/j.cub.2010.09.060","article-title":"Structural long-term changes at mushroom body input synapses","volume":"20","author":"Kremer","year":"2010","journal-title":"Current Biology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1038\/nrn964","article-title":"Olfactory network dynamics and the coding of multidimensional signals","volume":"3","author":"Laurent","year":"2002","journal-title":"Nature Reviews. Neuroscience"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"4065","DOI":"10.1242\/dev.126.18.4065","article-title":"Development of the Drosophila mushroom bodies: sequential generation of three distinct types of neurons from a neuroblast","volume":"126","author":"Lee","year":"1999","journal-title":"Development"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.bbrc.2013.05.036","article-title":"The GABA system regulates the sparse coding of odors in the mushroom bodies of Drosophila","volume":"436","author":"Lei","year":"2013","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1002\/cne.22184","article-title":"Synaptic organization in the adult Drosophila mushroom body calyx","volume":"517","author":"Leiss","year":"2009","journal-title":"The Journal of Comparative Neurology"},{"key":"bib60","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960902)372:4","article-title":"GABAergic Synapses in the Antenna1 Lobe and Mushroom Body of the Locust Olfactory System","volume":"372","author":"Leitch","year":"1996","journal-title":"The journal of comparative neurology"},{"key":"bib61","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62576","article-title":"The connectome of the adult Drosophila mushroom body provides insights into function","volume":"9","author":"Li","year":"2020","journal-title":"eLife"},{"key":"bib62","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108138","article-title":"Visual Input into the Drosophila melanogaster Mushroom Body","volume":"32","author":"Li","year":"2020","journal-title":"Cell Reports"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.cell.2007.03.006","article-title":"A map of olfactory representation in the Drosophila mushroom body","volume":"128","author":"Lin","year":"2007","journal-title":"Cell"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nn.3660","article-title":"Sparse, decorrelated odor coding in the mushroom body enhances learned odor discrimination","volume":"17","author":"Lin","year":"2014","journal-title":"Nature Neuroscience"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.neuron.2017.01.030","article-title":"Optimal Degrees of Synaptic Connectivity","volume":"93","author":"Litwin-Kumar","year":"2017","journal-title":"Neuron"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.neuron.2007.10.036","article-title":"GABAA receptor RDL inhibits Drosophila olfactory associative learning","volume":"56","author":"Liu","year":"2007","journal-title":"Neuron"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nn.2235","article-title":"The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning","volume":"12","author":"Liu","year":"2009","journal-title":"Nature Neuroscience"},{"key":"bib68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1709037115","article-title":"Cyclic AMP-Dependent Plasticity Underlies Rapid Changes in Odor Coding Associated with Reward Learning","volume":"20","author":"Louis","year":"2017","journal-title":"PNAS"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"10713","DOI":"10.1073\/pnas.1005635107","article-title":"Generating Sparse and Selective Third-Order Responses in the Olfactory System of the Fly","volume":"107","author":"Luo","year":"2010","journal-title":"PNAS"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.1016\/J.CUB.2020.06.028","article-title":"Connectomics Analysis Reveals First-, Second-, and Third-Order Thermosensory and Hygrosensory Neurons in the Adult Drosophila Brain","volume":"30","author":"Marin","year":"2020","journal-title":"Current Biology"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1113\/jphysiol.1969.sp008820","article-title":"A Theory of Cerebellar Cortex","volume":"202","author":"Marr","year":"1969","journal-title":"The Journal of Physiology"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.neuron.2018.07.050","article-title":"Developmental Coordination during Olfactory Circuit Remodeling in Drosophila","volume":"99","author":"Mayseless","year":"2018","journal-title":"Neuron"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1126\/science.1062622","article-title":"The role of Drosophila mushroom body signaling in olfactory memory","volume":"293","author":"McGuire","year":"2001","journal-title":"Science"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1126\/science.1089035","article-title":"Spatiotemporal rescue of memory dysfunction in Drosophila","volume":"302","author":"McGuire","year":"2003","journal-title":"Science"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/j.cub.2019.03.070","article-title":"Extreme Compartmentalization in a Drosophila Amacrine Cell","volume":"29","author":"Meier","year":"2019","journal-title":"Current Biology"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/s0896-6273(03)00200-9","article-title":"Shunting inhibition modulates neuronal gain during synaptic excitation","volume":"38","author":"Mitchell","year":"2003","journal-title":"Neuron"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-14836-6","article-title":"Multiple network properties overcome random connectivity to enable stereotypic sensory responses","volume":"11","author":"Mittal","year":"2020","journal-title":"Nature Communications"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep21841","article-title":"DoOR 2.0 - Comprehensive Mapping of Drosophila melanogaster Odorant Responses","volume":"6","author":"M\u00fcnch","year":"2016","journal-title":"Scientific Reports"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1038\/nature06864","article-title":"Lateral presynaptic inhibition mediates gain control in an olfactory circuit","volume":"452","author":"Olsen","year":"2008","journal-title":"Nature"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.neuron.2010.04.009","article-title":"Divisive normalization in olfactory population codes","volume":"66","author":"Olsen","year":"2010","journal-title":"Neuron"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.conb.2004.07.007","article-title":"Sparse coding of sensory inputs","volume":"14","author":"Olshausen","year":"2004","journal-title":"Current Opinion in Neurobiology"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1126\/science.1201835","article-title":"Normalization for sparse encoding of odors by a wide-field interneuron","volume":"332","author":"Papadopoulou","year":"2011","journal-title":"Science"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.neuron.2013.08.006","article-title":"Odor discrimination in Drosophila: from neural population codes to behavior","volume":"79","author":"Parnas","year":"2013","journal-title":"Neuron"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1016\/j.celrep.2015.02.065","article-title":"Optical dissection of experience-dependent pre- and postsynaptic plasticity in the Drosophila brain","volume":"10","author":"Pech","year":"2015","journal-title":"Cell Reports"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1126\/science.1070502","article-title":"Oscillations and sparsening of odor representations in the mushroom body","volume":"297","author":"Perez-Orive","year":"2002","journal-title":"Science"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.cub.2011.03.069","article-title":"A pair of inhibitory neurons are required to sustain labile memory in the Drosophila mushroom body","volume":"21","author":"Pitman","year":"2011","journal-title":"Current Biology"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/nature03687","article-title":"Invariant visual representation by single neurons in the human brain","volume":"435","author":"Quiroga","year":"2005","journal-title":"Nature"},{"key":"bib88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250381","article-title":"The number of neurons in Drosophila and mosquito brains","volume":"16","author":"Raji","year":"2021","journal-title":"PLOS ONE"},{"key":"bib89","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53281","article-title":"Feedback inhibition and its control in an insect olfactory circuit","volume":"9","author":"Ray","year":"2020","journal-title":"eLife"},{"key":"bib90","volume-title":"Bush, and Society for Experimental Biology","author":"Roberts","year":"1981"},{"key":"bib91","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1152\/jn.1995.73.2.713","article-title":"Sparseness of the neuronal representation of stimuli in the primate temporal visual cortex","volume":"73","author":"Rolls","year":"1995","journal-title":"Journal of Neurophysiology"},{"key":"bib92","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.neuron.2011.05.012","article-title":"Pattern separation: a common function for new neurons in hippocampus and olfactory bulb","volume":"70","author":"Sahay","year":"2011","journal-title":"Neuron"},{"key":"bib93","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2013.00096","article-title":"Reassessing pattern separation in the dentate gyrus","volume":"7","author":"Santoro","year":"2013","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"bib94","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57443","article-title":"A connectome and analysis of the adult Drosophila central brain","volume":"9","author":"Scheffer","year":"2020","journal-title":"eLife"},{"key":"bib95","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nature Methods"},{"key":"bib96","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/s0306-4522(00)00548-0","article-title":"Unsupervised learning of granule cell sparse codes enhances cerebellar adaptive control","volume":"103","author":"Schweighofer","year":"2001","journal-title":"Neuroscience"},{"key":"bib97","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198745273.003.0012","volume-title":"Principles of Dendritic Integration","author":"Spruston","year":"2016"},{"key":"bib98","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/BF00327741","article-title":"Neuronal architecture of the antennal lobe in Drosophila melanogaster","volume":"262","author":"Stocker","year":"1990","journal-title":"Cell and Tissue Research"},{"key":"bib99","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/(sici)1097-4695(199705)32:5<443::aid-neu1>3.0.co;2-5","article-title":"Neuroblast ablation in Drosophila P[GAL4] lines reveals origins of olfactory interneurons","volume":"32","author":"Stocker","year":"1997","journal-title":"Journal of Neurobiology"},{"key":"bib100","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/0896-6273(95)90290-2","article-title":"Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects","volume":"14","author":"Sweeney","year":"1995","journal-title":"Neuron"},{"key":"bib101","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1523\/JNEUROSCI.1448-18.2018","article-title":"Pathway-Specific Drive of Cerebellar Golgi Cells Reveals Integrative Rules of Cortical Inhibition","volume":"39","author":"Tabuchi","year":"2019","journal-title":"The Journal of Neuroscience"},{"key":"bib102","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1073\/pnas.1106377109","article-title":"Spatial organization of the extracellular matrix regulates cell-cell junction positioning","volume":"109","author":"Tseng","year":"2012","journal-title":"PNAS"},{"key":"bib103","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1209\/0295-5075\/6\/2\/002","article-title":"The Enhanced Storage Capacity in Neural Networks with Low Activity Level","volume":"6","author":"Tsodyks","year":"1988","journal-title":"Europhysics Letters"},{"key":"bib104","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1152\/jn.01283.2007","article-title":"Olfactory representations by Drosophila mushroom body neurons","volume":"99","author":"Turner","year":"2008","journal-title":"Journal of Neurophysiology"},{"key":"bib105","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1098\/rstb.1992.0059","article-title":"Cerebellar cortex: its simulation and the relevance of Marr\u2019s theory","volume":"336","author":"Tyrrell","year":"1992","journal-title":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences"},{"key":"bib106","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1088\/0305-4470\/22\/5\/018","article-title":"Optimised network for sparsely coded patterns","volume":"22","author":"Vicente","year":"1989","journal-title":"Journal of Physics A"},{"key":"bib107","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1126\/science.287.5456.1273","article-title":"Sparse coding and decorrelation in primary visual cortex during natural vision","volume":"287","author":"Vinje","year":"2000","journal-title":"Science"},{"key":"bib108","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1046\/j.1460-9568.1999.00678.x","article-title":"Cerebellar Golgi cells in the rat: receptive fields and timing of responses to facial stimulation","volume":"11","author":"Vos","year":"1999","journal-title":"The European Journal of Neuroscience"},{"key":"bib109","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/s0092-8674(00)00021-0","article-title":"An olfactory sensory map in the fly brain","volume":"102","author":"Vosshall","year":"2000","journal-title":"Cell"},{"key":"bib110","doi-asserted-by":"publisher","DOI":"10.1101\/819227","article-title":"The Reconstruction and Functional Mapping of a Recurrent Microcircuit in Drosophila Mushroom Body","volume-title":"bioRxiv","author":"Wang","year":"2019"},{"key":"bib111","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.1016\/j.cub.2013.09.056","article-title":"An octopamine-mushroom body circuit modulates the formation of anesthesia-resistant memory in Drosophila","volume":"23","author":"Wu","year":"2013","journal-title":"Current Biology"},{"key":"bib112","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/cne.10155","article-title":"Synaptic organization of the mushroom body calyx in Drosophila melanogaster","volume":"445","author":"Yasuyama","year":"2002","journal-title":"The Journal of Comparative Neurology"},{"key":"bib113","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.cell.2018.06.019","article-title":"A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster","volume":"174","author":"Zheng","year":"2018","journal-title":"Cell"},{"key":"bib114","doi-asserted-by":"publisher","DOI":"10.1101\/2020.04.17.047167","article-title":"Structured Sampling of Olfactory Input by the Fly Mushroom Body","volume-title":"bioRxiv","author":"Zheng","year":"2020"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/74172\/elife-74172-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/74172\/elife-74172-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/74172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:23:38Z","timestamp":1697059418000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/74172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,29]]},"references-count":114,"alternative-id":["10.7554\/eLife.74172"],"URL":"https:\/\/doi.org\/10.7554\/elife.74172","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.20.461071","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2021.09.20.461071","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.74172.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.74172.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.74172.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,29]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e74172"}} |