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Archive MaleCNS research sources, provenance, bibliography and immutable data inventory

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Digital Drosophila Archive
2026-09-29 03:38:32 +08:00
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/audit/base-input-sha256.json
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/audit/final-summary.json
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/audit/frozen-integrity-after.json
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/audit/frozen-integrity-before.json
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/audit/phase4i.yaml
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phase: 4I
name: MaleCNS-MB-mechanistic-validation-v1
paths:
connectome_root: /data/digital-drosophila/datasets/male-cns-v1.0/processed/neuron-only
model_root: /data/digital-drosophila/models/male-cns-lif
phase4i_model_root: /data/digital-drosophila/models/male-cns-lif/mb-mechanistic-v1
experiment_root: /data/digital-drosophila/experiments/phase4i-mb-mechanistic-validation
reference_root: /data/digital-drosophila/models/male-cns-lif/reference-v1
runtime_root: /data/digital-drosophila/models/male-cns-lif/runtime-v1
io_root: /data/digital-drosophila/models/male-cns-lif/io-v1
phase4c_root: /data/digital-drosophila/experiments/phase4c-runtime
phase4d_root: /data/digital-drosophila/experiments/phase4d-io
phase4e_root: /data/digital-drosophila/experiments/phase4e-visual-calibration
phase4f_root: /data/digital-drosophila/experiments/phase4f-retinotopic-vision
phase4f_model_root: /data/digital-drosophila/models/male-cns-lif/visual-encoder-v1
phase4g_root: /data/digital-drosophila/experiments/phase4g-frozen-interface
phase4g_model_root: /data/digital-drosophila/models/male-cns-lif/frozen-interface-v1
phase4g_learned_root: /data/digital-drosophila/models/learned/phase4g
phase4h_root: /data/digital-drosophila/experiments/phase4h-dopamine-plasticity
phase4h_model_root: /data/digital-drosophila/models/male-cns-lif/dopamine-plasticity-v1
phase4h_learned_root: /data/digital-drosophila/models/learned/phase4h
expected_graph:
neurons: 166700
directed_edges: 25582938
synaptic_contact_weight_sum: 124177617
phase4h_plastic_candidate_edges: 14232
names:
reference: MaleCNS-LIF-reference-v1
runtime: MaleCNS-LIF-runtime-v1
model:
dt_ms: 0.1
membrane_tau_ms: 20.0
synaptic_tau_ms: 5.0
refractory_ms: 2.2
resting_potential_mv: -52.0
reset_potential_mv: -52.0
threshold_mv: -45.0
synaptic_delay_ms: 1.8
w_syn_mv_per_anatomical_synapse: 0.275
sign_policy:
neurotransmitter_sign: {acetylcholine: 1, gaba: -1, glutamate: -1, dopamine: 1, octopamine: 1, serotonin: 1, histamine: -1}
unknown_sign: 0
unclear_sign: 0
readout:
bins_ms: [1, 5, 10, 20, 50, 100]
device:
required_name_substring: RTX 4090
launcher_visible_gpu_uuid: GPU-79f3a85d-adce-7833-7003-6488140ca596
olfactory_audit:
seeds: [48101, 48102, 48103, 48104, 48105]
rate_hz: 50.0
duration_ms: 100.0
targets_per_identity: 64
temporal_bin_ms: 10.0
consensus_seed_count: 3
separability_gate:
maximum_mean_active_jaccard: 0.8
minimum_pair_cosine_distance: 0.01
majority_seeds: 3
between_exceeds_within_sigma: 2.0
direct_kc:
ensemble_size: 64
target_compartment_verbatim: "y5B'2a"
matched_dan_type: PAM15
unrelated_compartment_verbatim: "y2a'1"
unrelated_dan_type: PPL103
pulse_times_ms: [10.0, 30.0, 50.0, 70.0, 90.0]
evaluation_duration_ms: 120.0
conditioning_trials: 3
train_seeds: [49001, 49002, 49003, 49004, 49005]
evaluation_seeds: [49101, 49102, 49103, 49104, 49105]
plasticity:
overlay_equation: effective_weight = base_weight + plastic_delta
eta_effective_mv: 0.00275
eligibility_tau_ms: 1000.0
polarity: -1
max_fractional_depression_per_edge: 0.25
negative_delay_behavior_under_phase4h_rule: full_eligibility
timing:
delta_t_ms: [-1000, -500, -250, -100, -50, 0, 50, 100, 250, 500, 1000]
common_kc_time_ms: 1000.0
trial_duration_ms: 2100.0
seed: 49201
far_to_coincident_nonspecific_ratio: 0.1
controls:
conditions: [A-matched-DAN, A-D-zero, A-unrelated-DAN, B-matched-DAN, random-KC-DAN, frozen-no-plasticity]
prohibitions:
modify_base_csr: false
modify_w_syn: false
modify_transmitter_sign: false
modify_lif_parameters: false
expand_plastic_mask: false
tune_eta_or_polarity: false
brain_backpropagation: false
reinforcement_learning: false
visual_or_game_integration: false
registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/audit/phase4i_final_report.json
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{
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"reason": "Both conditions activated all 4,064 KCs in all five deterministic seeds."
},
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"union": 4064,
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"3_plastic_edge_eligibility_overlap": {
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"label": "FAIL-PLASTICITY-MECHANISM",
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},
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"6_compartment_locality": {
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"target_compartment_updates": 200,
"off_compartment_updates": 0,
"inactive_edge_updates": 0,
"stimulus_source_locality_correct": false,
"A_injected_source_updates": 67,
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},
"7_eligibility_timing_curve": {
"status": "FAIL-ELIGIBILITY-TIMING",
"secondary_label": "ELIGIBILITY-TIMING-NONSPECIFIC",
"far_abs_dt_ge_500_to_zero_ratio": 0.7436025322625082,
"negative_delays_receive_full_eligibility": true,
"positive_delay_decay": "exp(-delta_t/1000ms)"
},
"8_maximum_plasticity_delta_t_ms": [-1000, -500, -250, -100, -50, 0],
"9_unit_tests": {
"passed": 8,
"total": 8,
"all_passed": true
},
"10_MBON_changed_metrics": {
"subthreshold_g": true,
"subthreshold_voltage": true,
"spike_count": false,
"first_spike_latency": false,
"population_separation_improved": false,
"effect_exceeds_1e-4_noise_floor": true
},
"11_causal_evidence": {
"actual_KC_to_MBON_to_downstream_paths_saved": 20,
"all_KC_MBON_edges_are_in_frozen_mask": true,
"structural_path_confirmed": true,
"A_specific_functional_spike_change_confirmed": false
},
"12_controls": {
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"frozen_changed_edges": 0,
"unrelated_DAN_changed_edges": 202,
"B_matched_DAN_changed_edges": 177,
"random_KC_DAN_changed_edges": 2109,
"associative_specificity_pass": false
},
"13_five_seed_consistency": {
"A_subthreshold_change": "5/5",
"A_spike_change": "0/5",
"B_preserved": "0/5",
"direct_memory_pass": "0/5"
},
"14_mechanism_labels": [
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"PLASTIC-EDGE-REPRESENTATION-OVERLAP",
"FAIL-PLASTICITY-MECHANISM",
"FAIL-ELIGIBILITY-TIMING"
],
"15_frozen_integrity": {
"phase_1_to_4H_checksums": "PASS",
"phase4C_reference_regression": "PASS",
"BrainIO_v1": "PASS",
"ActivityStream_v1": "PASS",
"base_CSR_unchanged": true
},
"stopped_before_phase4J": true
}
registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/causal-validation/summary.json
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{
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"population_correlation_used_as_connectivity_substitute": false,
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},
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}
registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/compartment-locality/summary.json
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{
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"training": [
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"trial": 0,
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}
registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/controls/A-D-zero/summary.json
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{
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/controls/A-matched-DAN/summary.json
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{
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/controls/A-unrelated-DAN/summary.json
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/controls/B-matched-DAN/summary.json
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/controls/frozen-no-plasticity/summary.json
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/controls/random-KC-DAN/summary.json
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/controls/summary.json
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/direct-kc-memory/summary.json
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{
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/regression/phase4c-reference-replay.json
+33
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@@ -0,0 +1,33 @@
{
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/timing-curve/summary.json
+159
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@@ -0,0 +1,159 @@
{
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registry/catalog-20260929/evidence/phase4i-mb-mechanistic-validation/unit-tests/summary.json
+13
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@@ -0,0 +1,13 @@
{
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