{
  "status": "TRANSMITTER-IDENTITY-INTERPRETATION-WARNING",
  "DAN_label_definition_in_4W": "neurotransmitter metadata equals dopamine, not independently verified anatomical DAN identity",
  "DPM_input_metadata": [
    {
      "neuron_idx": 2403,
      "body_id": 12569,
      "annotation_class": null,
      "annotation_type": "DPM",
      "annotation_subclass": null,
      "annotation_superclass": "cb_intrinsic",
      "neurotransmitter": "dopamine",
      "audit_category": "DAN"
    }
  ],
  "late_positive_contributions": [
    {
      "target_neuron_idx": 59832,
      "DPM_fraction_all_positive": 0.0706060454249382,
      "DPM_fraction_metadata_dopamine_positive": 0.29459211230278015,
      "metadata_dopamine_fraction_all_positive": 0.239673912525177
    },
    {
      "target_neuron_idx": 78836,
      "DPM_fraction_all_positive": 0.3121650218963623,
      "DPM_fraction_metadata_dopamine_positive": 0.3416522741317749,
      "metadata_dopamine_fraction_all_positive": 0.9136922359466553
    },
    {
      "target_neuron_idx": 82312,
      "DPM_fraction_all_positive": 0.0,
      "DPM_fraction_metadata_dopamine_positive": 0.0,
      "metadata_dopamine_fraction_all_positive": 0.00624917633831501
    }
  ],
  "frozen_signs_changed": false,
  "simulations_rerun": false,
  "conclusion": "Do not interpret omit_DAN as selective removal of confirmed reward DANs. It removes the operational metadata-dopamine group, including DPM.",
  "causal_limit": "Neither DPM-only necessity nor whole-brain causal necessity was tested. Literature is not proof of the true transmitter/sign for these exact MaleCNS bodies.",
  "source_access": {
    "Haynes2015": "PMC full text retrieved",
    "Eckstein2024": "PubMed bibliographic record and PMC/ETH search-index excerpts; PMC CAPTCHA and ETH direct PDF 403",
    "MaleCNS_authors_repository": "https://github.com/funkelab/synister_malecns"
  },
  "sources": [
    {
      "title": "Haynes et al. 2015, A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4305081/",
      "doi": "10.7554/eLife.03868"
    },
    {
      "title": "Eckstein et al. 2024, Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11106717/",
      "doi": "10.1016/j.cell.2024.03.016"
    }
  ],
  "sealed_4W_integrity_before": {
    "root": "/data/digital-drosophila/experiments/phase4w-late-kc-feedback",
    "checked": 214,
    "pass": true,
    "control_sha256": "cbc90feefc335c1b49f2121e5364459dc2f1c6d4dc6d5b3cf1a7ecb1a5058dc7"
  },
  "sealed_4W_integrity_after": {
    "root": "/data/digital-drosophila/experiments/phase4w-late-kc-feedback",
    "checked": 214,
    "pass": true,
    "control_sha256": "cbc90feefc335c1b49f2121e5364459dc2f1c6d4dc6d5b3cf1a7ecb1a5058dc7"
  }
}